![]() The Safe Grapefruit? By The American Botanical Council.Reference Links Substantiating Possible Skin Issues of Grapefruit Oil: Startlingly, furocoumarins are also used in different remedies along with the long-wave ultraviolet light therapy for curing psoriasis, mycosis fungoides and vitiligo. ![]() Use Grapefruit oil only after medical advice, if you are taking any other prescription medicines. ![]() The presence of furocoumarins has led to the term ‘ Grapefruit effect’, which signifies the interaction between furocoumarins and enzymes that are engaged in drug metabolism, specifically cytochrome P450. In a much similar way like Bitter orange oil, Grapefruit oil is said to restrain important enzymes in the intestines and liver, leading to have an impact on the blood levels at the time of taking medicines that are antidepressant, antiviral, anti-anxiety, calcium channel blockers, steroids, anti-malarial, immune modulators, prokinetics, statins and on par with caffeine intake. It is better to avoid Grapefruit oil if you are pregnant or breastfeeding as the safety of this oil during carrying or nursing are not established. Studies state that ingesting furocoumarins may also cause phytophotodermatitis. Undiluted Grapefruit oil can cause skin irritation and this oil is claimed to be toxic to cats.Ī 2005 study published in Brain Research states that “the scent of Grapefruit oil and its active constituent, limonene affects the autonomic neurotransmission and blood pressure through central histaminergic nerves and the suprachiasmatic nucleus.” Grapefruit oil should be used only for topical application, preferably blended with mild carrier oils (good for use after a patch test on your skin), and never use essential oils for ingestion, as internal use of essential oils might pose adverse health effects. This is particularly to prevent phototoxicity in products used for dermal applications except for bath products like soaps, shampoos and other wash-off preparations.Īccording to the European decree, essential oils that contain furanocoumarins must be used preferably when the level of bergapten does not exceed 15 ppm (parts per million) in finished cosmetic products preordained for use on parts of the skin that are in contact with sunlight (other than rinse-away products) and 1 ppm in bronzing and sun protection products. The safe dilution level of Grapefruit oil by the International Fragrance Association (IFRA) is 4%, which is about 24 drops per ounce of any mild carrier oils. The primary chemical component responsible for the phototoxic and adverse skin effects of Grapefruit oil is Limonene, which accounts to about 90% of this oil along with few other furanocoumarins ( the non-volatile compounds like bergapten, bergamottin and epoxy-bergamottin.) Certain studies state that Grapefruit oil has been stated to promote the formation of tumors on the skin of mouse, by the key carcinogen, 10-dimethyl-l, 2-benzanthracene. The underlying reason is the reaction of the photoactive chemical constituents in Grapefruit oil that attracts light and leads to toxicity through molecular changes in the skin surface. The possible skin issues of using Grapefruit oil are hyperpigmentation, allergic reactions, irritation, sunburns, blisters and rashes and this mainly occurs when the skin is exposed to visible sunlight for up to 12 hours of use of this oil. Grapefruit oil showcases photosensitive effects if oxidized, contributing to its phototoxic, photo-carcinogenic and effects of sensitization. GC/MS Tested 1kg and 4oz Pure Essential Oils > CLICK HERE > CLICK HERE 3 – Possible Skin Issues:
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